Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00379814" target="_blank" >RIV/68378041:_____/12:00379814 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.exger.2012.04.003" target="_blank" >http://dx.doi.org/10.1016/j.exger.2012.04.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exger.2012.04.003" target="_blank" >10.1016/j.exger.2012.04.003</a>
Alternative languages
Result language
angličtina
Original language name
Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat
Original language description
Age-related changes in the expression of intracellular calcium buffers calbindin and calretinin were evaluated in the central auditory structures in two rat strains, the slowly aging Long-Evans and the fast aging Fischer 344 rats. Our results demonstrated significant age-related decrease in the number and volumes of immunoreactive neurons and decreased protein levels similarly in both rat strains regardless their differently preserved inner ear function. The decline in calbindin protein levels and number of calbindin expressing neurons was more pronounced in comparison with the changes in calretinin immunoreactivity. The observed age-related changes in the calbindin- and calretinin-expressing systems may contribute significantly to the deterioration ofhearing function known as central presbycusis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Gerontology
ISSN
0531-5565
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
497-506
UT code for WoS article
000304813200003
EID of the result in the Scopus database
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