Astrocytes and glutamate homeostasis in Alzheimer's disease: a decrease in glutamine synthetase but not in glutamate transporter-1 in the prefrontal cortex.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00397066" target="_blank" >RIV/68378041:_____/13:00397066 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1042/AN20130017" target="_blank" >http://dx.doi.org/10.1042/AN20130017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/AN20130017" target="_blank" >10.1042/AN20130017</a>

Result language
angličtina
Original language name
Astrocytes and glutamate homeostasis in Alzheimer's disease: a decrease in glutamine synthetase but not in glutamate transporter-1 in the prefrontal cortex.
Original language description
The expression of glutamine synthetase (GS) and glutamate transporter-1 (GLT-1) was analyzed in astrocytes during the progression of AD in a triple-transgenic mouse model. A significant decrease of GS expression was found, which may underlie a gradual decline in the astrocyte-dependent glutamate-glutamine conversion pathway, which in turn may compromise glutamate homoeostasis, leading towards failures in synaptic connectivity with deficient cognition and memory.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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