Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00367669" target="_blank" >RIV/68378041:_____/11:00367669 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1750-1326-6-55" target="_blank" >http://dx.doi.org/10.1186/1750-1326-6-55</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1750-1326-6-55" target="_blank" >10.1186/1750-1326-6-55</a>

Result language
angličtina
Original language name
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
Original language description
Here, we report a decline in astrocytic glutamine synthetase (GS) in two major cognitive areas of the hippocampus (the dentate gyrus, DG and the CA1) in 3xTg-AD animals) aged between 9 and 18 months. Such a decrease in astrocytic GS is directly associated with the presence of A? deposits indicating AD-related impairments of glutamate homeostatic system, at the advanced and late stages of the disease, which may affect the efficacy of glutamatergic transmission in the diseased brain that may contribute tothe cognitive deficiency.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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