Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00397105" target="_blank" >RIV/68378041:_____/13:00397105 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1113/jphysiol.2013.256875" target="_blank" >http://dx.doi.org/10.1113/jphysiol.2013.256875</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1113/jphysiol.2013.256875" target="_blank" >10.1113/jphysiol.2013.256875</a>
Alternative languages
Result language
angličtina
Original language name
Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity
Original language description
The calyx of Held synapse of the medial nucleus of the trapezoid body is a giant axosomatic synapse in the auditory brainstem, which acts as a relay synapse showing large number of release sites with low release probability. We investigated the contribution of presynaptic GABAB receptors and spontaneous activity to release probability both in vivo and in vitro in young-adult mice. Our data thus suggest that spontaneous firing can tonically reduce release probability in vivo. In addition, our data show that the ambient GABA concentration in the auditory brainstem is too low to activate the GABAB receptor at the calyx of Held significantly, but that activation of GABAB receptors can reduce sound-evoked synaptic depression. key words (3): GABAB, synaptictransmission, auditory
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F11%2F0131" target="_blank" >GAP303/11/0131: Ectopic release of glycine - physiological role and mechanism</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology
ISSN
0022-3751
e-ISSN
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Volume of the periodical
591
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
4877-4894
UT code for WoS article
000325151600017
EID of the result in the Scopus database
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