The role of GABAB receptors in the subcortical pathways of the mammalian auditory system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00574202" target="_blank" >RIV/68378041:_____/23:00574202 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10467055
Result on the web
<a href="https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1195038/full" target="_blank" >https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1195038/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fendo.2023.1195038" target="_blank" >10.3389/fendo.2023.1195038</a>
Alternative languages
Result language
angličtina
Original language name
The role of GABAB receptors in the subcortical pathways of the mammalian auditory system
Original language description
GABAB receptors are G-protein coupled receptors for the inhibitory neurotransmitter GABA. Functional GABAB receptors are formed as heteromers of GABAB1 and GABAB2 subunits, which further associate with various regulatory and signaling proteins to provide receptor complexes with distinct pharmacological and physiological properties. GABAB receptors are widely distributed in nervous tissue, where they are involved in a number of processes and in turn are subject to a number of regulatory mechanisms. In this review, we summarize current knowledge of the cellular distribution and function of the receptors in the inner ear and auditory pathway of the mammalian brainstem and midbrain. The findings suggest that in these regions, GABAB receptors are involved in processes essential for proper auditory function, such as cochlear amplifier modulation, regulation of spontaneous activity, binaural and temporal information processing, and predictive coding. Since impaired GABAergic inhibition has been found to be associated with various forms of hearing loss, GABAB dysfunction could also play a role in some pathologies of the auditory system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Endocrinology
ISSN
1664-2392
e-ISSN
1664-2392
Volume of the periodical
14
Issue of the periodical within the volume
aug.
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
1195038
UT code for WoS article
001082212100001
EID of the result in the Scopus database
2-s2.0-85168796550