The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric γ-Aminobutyrate B Receptor.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F02%3A19023072" target="_blank" >RIV/68378041:_____/02:19023072 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric γ-Aminobutyrate B Receptor.

Original language description

Our data revealed the following new information on the G-protein coupling of the heteromeric GABAB receptor: 1) the i2 loop of GB2 within the GB2 HD is required for the heteromeric GABAB receptor to couple to G-proteins, whereas the i2 loop of GB1 is not; 2) the presence of the i2 loop of GB2 within the GB1 HD is not sufficient to allow coupling of GB1; 3) the GB2 HD activates the Gqi9 protein whether it is associated with the GB2 or GB1 ECD; 4) in the combination with two GB2 HDs, each is able to couple to G-proteins.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Pharmacology

ISSN

0026-895X

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

343-350

UT code for WoS article

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EID of the result in the Scopus database

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