GABA(B) receptor phosphorylation regulates KCTD12-induced K+ current desensitization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00431570" target="_blank" >RIV/68378041:_____/14:00431570 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bcp.2014.07.013" target="_blank" >http://dx.doi.org/10.1016/j.bcp.2014.07.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bcp.2014.07.013" target="_blank" >10.1016/j.bcp.2014.07.013</a>

Result language

angličtina

Original language name

GABA(B) receptor phosphorylation regulates KCTD12-induced K+ current desensitization

Original language description

We studied modulation of KCTD12-induced desensitization of GABAB receptor activated K+ currents by protein kinase A (PKA). We found that PKA phosphorylation of S892 on the C-tail of GB2 subunit reduces KCTD12-induced desensitization. Mechanistically, S892 phosphorylation induces a conformational change in the GABAB receptor/KCTD12 complex that slows KCTD12-induced desensitization. Reciprocally, the binding of KCTD12 promotes phosphorylation of S892, consistent with previous data showing that KCTD12 stabilizes receptors at the cell surface.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Pharmacology

ISSN

0006-2952

e-ISSN

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Volume of the periodical

91

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

369-379

UT code for WoS article

000342272500010

EID of the result in the Scopus database

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