Chapter Six ? Mechanisms of Fast Desensitization of GABAB
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00458030" target="_blank" >RIV/68378041:_____/15:00458030 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/bs.apha.2014.11.004" target="_blank" >http://dx.doi.org/10.1016/bs.apha.2014.11.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.apha.2014.11.004" target="_blank" >10.1016/bs.apha.2014.11.004</a>
Alternative languages
Result language
angličtina
Original language name
Chapter Six ? Mechanisms of Fast Desensitization of GABAB
Original language description
GABAB receptors (GABABRs) regulate the excitability of most neurons in the central nervous system by modulating the activity of enzymes and ion channels. In the sustained presence of the neurotransmitter ?-aminobutyric acid, GABABRs exhibit a time-dependent decrease in the receptor response?a phenomenon referred to as homologous desensitization. Desensitization prevents excessive receptor influences on neuronal activity. Much work focused on the mechanisms of GABABR desensitization that operate at the receptor and control receptor expression at the plasma membrane. Over the past few years, it became apparent that GABABRs additionally evolved mechanisms for faster desensitization. These mechanisms operate at the G protein rather than at the receptor andinhibit G protein signaling within seconds of agonist exposure. The mechanisms for fast desensitization are ideally suited to regulate receptor-activated ion channel responses, which influence neuronal activity on a faster timescale than
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler
ISBN
978-0-12-802658-8
Number of pages of the result
21
Pages from-to
145-165
Number of pages of the book
270
Publisher name
Academic Press
Place of publication
New York
UT code for WoS chapter
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