Auxiliary GABA(B) Receptor Subunits Uncouple G Protein beta gamma Subunits from Effector Channels to Induce Desensitization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00430025" target="_blank" >RIV/68378041:_____/14:00430025 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neuron.2014.04.015" target="_blank" >http://dx.doi.org/10.1016/j.neuron.2014.04.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuron.2014.04.015" target="_blank" >10.1016/j.neuron.2014.04.015</a>

Result language
angličtina
Original language name
Auxiliary GABA(B) Receptor Subunits Uncouple G Protein beta gamma Subunits from Effector Channels to Induce Desensitization
Original language description
We studied mechanisms of KCTD12-induced desensitization of GABAB receptor activated K+ currents. Using proteomic and electrophysiological approaches, we now show that the desensitization results from a dual interaction of KCTD12 with the G protein: constitutive binding stabilizes the heterotrimeric G protein at the receptor, whereas dynamic binding to the receptor-activated Gbg subunits induces desensitization by uncoupling Gbg from the effector K+ channel. Our results show that GABAB receptors are endowed with fast and reversible desensitization by harnessing KCTD12 that intercepts Gbg signaling.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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