Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00424594" target="_blank" >RIV/68378041:_____/13:00424594 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00424594 RIV/00027162:_____/13:#0001051
Result on the web
<a href="http://dx.doi.org/10.1016/j.tox.2013.09.001" target="_blank" >http://dx.doi.org/10.1016/j.tox.2013.09.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tox.2013.09.001" target="_blank" >10.1016/j.tox.2013.09.001</a>
Alternative languages
Result language
angličtina
Original language name
Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression
Original language description
Benzo[a]pyrene (BaP) metabolism in RLE-6TN cells under inflammatory conditions, simulated using either recombinant TNF-, or a mixture of inflammatory mediators derived from activated alveolar macrophage cell line was analyzed. Inflammatory conditions significantly accelerated BaP metabolism, as evidenced by decreased levels of both parent BaP and its metabolites. The present data suggests that the CYP1B1-catalyzed metabolism of polycyclic aromatic hydrocarbons might contribute to their enhanced bioactivation and genotoxic effects under inflammatory conditions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP503%2F11%2F0142" target="_blank" >GAP503/11/0142: Genotoxic and non-genotoxic mechanisms involved in carcinogenicity of complex mixtures of air pollutants: toxicogenomic approach</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology
ISSN
0300-483X
e-ISSN
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Volume of the periodical
314
Issue of the periodical within the volume
1
Country of publishing house
IE - IRELAND
Number of pages
9
Pages from-to
30-38
UT code for WoS article
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EID of the result in the Scopus database
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