Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00431253" target="_blank" >RIV/68378041:_____/14:00431253 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/14:00431253
Result on the web
<a href="http://dx.doi.org/10.1002/glia.22721" target="_blank" >http://dx.doi.org/10.1002/glia.22721</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/glia.22721" target="_blank" >10.1002/glia.22721</a>

Result language
angličtina
Original language name
Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia
Original language description
The increased expression of HCN channels in reactive astrocytes was detected on mRNA and protein levels following ischemic injury and the presence of functional HCN channels and their modulation by cAMP and ZD7288 was revealed by patch-clamp technique. Our results demonstrate that regardless of the type of ischemic injury, reactive astrocytes express HCN channels, which could therefore be an important therapeutic target in post-stroke therapy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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