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Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00431253" target="_blank" >RIV/68378041:_____/14:00431253 - isvavai.cz</a>

  • Alternative codes found

    RIV/86652036:_____/14:00431253

  • Result on the web

    <a href="http://dx.doi.org/10.1002/glia.22721" target="_blank" >http://dx.doi.org/10.1002/glia.22721</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/glia.22721" target="_blank" >10.1002/glia.22721</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia

  • Original language description

    The increased expression of HCN channels in reactive astrocytes was detected on mRNA and protein levels following ischemic injury and the presence of functional HCN channels and their modulation by cAMP and ZD7288 was revealed by patch-clamp technique. Our results demonstrate that regardless of the type of ischemic injury, reactive astrocytes express HCN channels, which could therefore be an important therapeutic target in post-stroke therapy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Glia

  • ISSN

    0894-1491

  • e-ISSN

  • Volume of the periodical

    62

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    18

  • Pages from-to

    2004-2021

  • UT code for WoS article

    000344236000008

  • EID of the result in the Scopus database