Physiology of Ca2+ signalling in stem cells of different origins and differentiation stages.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459078" target="_blank" >RIV/68378041:_____/16:00459078 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/16:00460352 RIV/00216208:11130/16:10323805 RIV/00216208:11110/16:10323805

Result on the web

<a href="http://dx.doi.org/10.1016/j.ceca.2016.02.001" target="_blank" >http://dx.doi.org/10.1016/j.ceca.2016.02.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ceca.2016.02.001" target="_blank" >10.1016/j.ceca.2016.02.001</a>

Result language

angličtina

Original language name

Physiology of Ca2+ signalling in stem cells of different origins and differentiation stages.

Original language description

Stem cells (SCs) of different origins have brought hope as potential tools for the treatment of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Amyotrophic Lateral Sclerosis. Calcium signalling plays a key role in SC differentiation and proliferation, and dysregulation of Ca(2+) homeostasis may instigate pathological scenarios. Currently, the role of ion channels and receptors in SCs is not fully understood. In the recent years, we found that (i) the pre-differentiation of human embryonic SCs (hESCs) led to the activation of Ca(2+) signalling cascades and enhanced the functional activities of these cells, (ii) the Ca(2+) homeostasis and the physiological properties of hESC-derived neural precursors (NPs) changed during long term propagation in vitro, (iii) differentiation of NPs derived from human induced pluripotent SCs affects the expression of ion channels and receptors, (iv) these neuronal precursors exhibited spontaneous activity, indicating that their electrophysiological and Ca(2+) handling properties are similar to those of mature neurones, and (v) in mesenchymal SCs isolated from the adipose tissue and bone marrow of rats the expression profile of ion channels and receptors depends not only on the differentiation conditions but also on the source from which the cells were isolated, indicating that the fate and functional properties of the differentiated cells are driven by intrinsic mechanisms. Together, identification and assignment of a unique ion channel and a Ca(2+) handling footprint for each cell type would be necessary to qualify them as physiologically suitable for medical research, drug screening, and cell therapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Calcium

ISSN

0143-4160

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

2-3

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

57-66

UT code for WoS article

000375335900002

EID of the result in the Scopus database

2-s2.0-84958554912