Effects of Nanoparticles Exposure on mRNA Expression in Mice: a review of literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00475914" target="_blank" >RIV/68378041:_____/16:00475914 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of Nanoparticles Exposure on mRNA Expression in Mice: a review of literature

Original language description

Nanomaterials have become widely used not only in various industrial fields but also in consumer products. Thus, possible negative health effects impact not only professionals, but also general populationo. Therefore, understanding the mechanisms of genotoxicity of nanomaterials is imperative to avoid application of materials with properties that negatively affect cellular functions. To reveal such properties, analyzes of gene expression changes in model systems, preferably in vivo animal models, upon exposure to nanomaterials are conducted. In this article, we report the results of a review of literature concerning gene expression changes in mice exposed to nanoparticles. Using keywords „gene expression“, „mice“, „nanoparticles“ we identified 25 studies that analyzed the effect of nine types of nanoparticles. Titanium dioxide, silver and gold were the most commonly studied ones. Vast majority of studies detected negative changes in mice upon exposure to nanoparticles. They primarily included alterations of expression of genes related to oxidative stress response and inflammation, although other pathways ( apoptosis, cell cycleregulation, metabolism, cell differentiation or cell proliferation) were also affected. Interestingly, the changes were even for those nanoparticles, that are considered biologically safe (i.e. titanium dioxide, or gold). These observations underline the fact that nanomaterials should require thorough testing before they are approved for general application in consumer products.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LO1508" target="_blank" >LO1508: Genomics and proteomics in the study of mechanisms of biological effects of produced nanoparticles</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Novel Biomaterials in Regenerative Medicine

ISBN

978-80-88113-69-0

Number of pages of the result

14

Pages from-to

18-31

Number of pages of the book

276

Publisher name

Epika

Place of publication

2016

UT code for WoS chapter

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