Multipotency and therapeutic potential of NG2 cells.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476751" target="_blank" >RIV/68378041:_____/17:00476751 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bcp.2017.05.008" target="_blank" >http://dx.doi.org/10.1016/j.bcp.2017.05.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bcp.2017.05.008" target="_blank" >10.1016/j.bcp.2017.05.008</a>
Alternative languages
Result language
angličtina
Original language name
Multipotency and therapeutic potential of NG2 cells.
Original language description
NG2 cells represent one of the most proliferative glial cell populations in the intact mammalian central nervous system (CNS). They are well-known for their ability to renew themselves or to generate new oligodendrocytes during development as well as in adulthood, therefore also being termed oligodendrocyte progenitor cells. Following CNS injuries, such as demyelination, trauma or ischemia, the proliferative capacity of NG2 cells rapidly increases and moreover, their differentiation potential broadens, as documented by numerous reports also describing their differentiation into astrocytes or even neurons. Here, we summarize the current knowledge about NG2 cells proliferation, their fate plasticity during embryogenesis as well as in postnatal CNS under physiological and pathological conditions, with the main emphasis on the role of various signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG2 cells. (c) 2017 Elsevier Inc. All rights reserved.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA17-04034S" target="_blank" >GA17-04034S: Principal signaling pathways regulating NG2 glia proliferation and differentiation following brain injuries</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical Pharmacology
ISSN
0006-2952
e-ISSN
—
Volume of the periodical
141
Issue of the periodical within the volume
SI
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
42-55
UT code for WoS article
000411656600004
EID of the result in the Scopus database
2-s2.0-85019637465