MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00480904" target="_blank" >RIV/68378041:_____/17:00480904 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10364798 RIV/00064190:_____/17:N0000010 RIV/00064165:_____/17:10364798
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/gex026" target="_blank" >http://dx.doi.org/10.1093/mutage/gex026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/gex026" target="_blank" >10.1093/mutage/gex026</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis
Original language description
Here we provide the first evidence that variations in potential miRNA target binding sites in the 3UTR of PARP1 gene may modulate CRC risk and prognosis after therapy. We investigated eight miRSNPs (rs1804191, rs397768, rs41116 in APC, rs1137918, s227091, rs4585 in ATM, rs712, rs1137282, rs61764370 in KRAS, rs8674 in PARP1 and rs16950113 in SMAD7) for their association with CRC risk in a case–control study (1111 cases and 1469 healthy controls). The role of these miRSNPs was also investigated in relation to clinical outcome on a subset of patients with complete follow-up.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutagenesis
ISSN
0267-8357
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
533-542
UT code for WoS article
000413218700007
EID of the result in the Scopus database
2-s2.0-85032489277