Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00481164" target="_blank" >RIV/68378041:_____/17:00481164 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.26956" target="_blank" >http://dx.doi.org/10.7554/eLife.26956</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.26956" target="_blank" >10.7554/eLife.26956</a>

Result language

angličtina

Original language name

Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Original language description

Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone and then elongate. Failure of regeneration was associated with increased retraction after axotomy. Transportation into axons becomes selective with maturation, we hypothesized that selective exclusion of molecules needed for growth may contribute to regeneration decline. With neuronal maturity rab11 vesicles (which carry many molecules involved in axon growth) became selectively targeted to the somatodendritic compartment and excluded from axons by predominant retrograde transport However, on overexpression rab11 was mistrafficked into proximal axons, and these axons showed less retraction and enhanced regeneration after axotomy. These results suggest that the decline of intrinsic axon regenerative ability is associated with selective exclusion of key molecules, and that manipulation of transport can enhance regeneration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

aug

Country of publishing house

GB - UNITED KINGDOM

Number of pages

25

Pages from-to

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UT code for WoS article

000411664100001

EID of the result in the Scopus database

2-s2.0-85030710450