Integrins promote axonal regeneration after injury of the nervous system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00492415" target="_blank" >RIV/68378041:_____/18:00492415 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/brv.12398" target="_blank" >http://dx.doi.org/10.1111/brv.12398</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/brv.12398" target="_blank" >10.1111/brv.12398</a>
Alternative languages
Result language
angličtina
Original language name
Integrins promote axonal regeneration after injury of the nervous system
Original language description
Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Reviews
ISSN
1464-7931
e-ISSN
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Volume of the periodical
93
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
24
Pages from-to
1339-1362
UT code for WoS article
000438196200002
EID of the result in the Scopus database
2-s2.0-85042054557