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Integrins promote axonal regeneration after injury of the nervous system

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00492415" target="_blank" >RIV/68378041:_____/18:00492415 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/brv.12398" target="_blank" >http://dx.doi.org/10.1111/brv.12398</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/brv.12398" target="_blank" >10.1111/brv.12398</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Integrins promote axonal regeneration after injury of the nervous system

  • Original language description

    Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biological Reviews

  • ISSN

    1464-7931

  • e-ISSN

  • Volume of the periodical

    93

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    24

  • Pages from-to

    1339-1362

  • UT code for WoS article

    000438196200002

  • EID of the result in the Scopus database

    2-s2.0-85042054557