Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493287" target="_blank" >RIV/68378041:_____/18:00493287 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/18:PU128365

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.34465" target="_blank" >http://dx.doi.org/10.7554/eLife.34465</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.34465" target="_blank" >10.7554/eLife.34465</a>

Result language

angličtina

Original language name

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Original language description

Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

jun 13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

27

Pages from-to

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UT code for WoS article

000436227500001

EID of the result in the Scopus database

2-s2.0-85051954949