Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU132818" target="_blank" >RIV/00216305:26620/19:PU132818 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage
Original language description
Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupl
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů