Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00096667" target="_blank" >RIV/00216224:14110/17:00096667 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/17:PU123303

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >http://dx.doi.org/10.7554/eLife.25902</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >10.7554/eLife.25902</a>

Result language

angličtina

Original language name

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Original language description

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

e25902

Country of publishing house

GB - UNITED KINGDOM

Number of pages

37

Pages from-to

1-37

UT code for WoS article

000400576600001

EID of the result in the Scopus database

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