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Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00096667" target="_blank" >RIV/00216224:14110/17:00096667 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26620/17:PU123303

  • Result on the web

    <a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >http://dx.doi.org/10.7554/eLife.25902</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >10.7554/eLife.25902</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

  • Original language description

    Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10600 - Biological sciences

Result continuities

  • Project

    <a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    eLife

  • ISSN

    2050-084X

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    e25902

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    37

  • Pages from-to

    1-37

  • UT code for WoS article

    000400576600001

  • EID of the result in the Scopus database