Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00096667" target="_blank" >RIV/00216224:14110/17:00096667 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/17:PU123303
Result on the web
<a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >http://dx.doi.org/10.7554/eLife.25902</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.25902" target="_blank" >10.7554/eLife.25902</a>
Alternative languages
Result language
angličtina
Original language name
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
Original language description
Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
e25902
Country of publishing house
GB - UNITED KINGDOM
Number of pages
37
Pages from-to
1-37
UT code for WoS article
000400576600001
EID of the result in the Scopus database
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