Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00507337" target="_blank" >RIV/68378041:_____/18:00507337 - isvavai.cz</a>
Result on the web
<a href="https://www.jneurosci.org/content/38/47/10102" target="_blank" >https://www.jneurosci.org/content/38/47/10102</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1523/JNEUROSCI.1122-18.2018" target="_blank" >10.1523/JNEUROSCI.1122-18.2018</a>
Alternative languages
Result language
angličtina
Original language name
Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Original language description
In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan using a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin-expressing inhibitory interneurons toward a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience
ISSN
0270-6474
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
47
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
10102-10113
UT code for WoS article
000450732900007
EID of the result in the Scopus database
2-s2.0-85056952441