Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00559934" target="_blank" >RIV/68378050:_____/21:00559934 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2073-4409/10/6/1345" target="_blank" >https://www.mdpi.com/2073-4409/10/6/1345</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells10061345" target="_blank" >10.3390/cells10061345</a>
Alternative languages
Result language
angličtina
Original language name
Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins
Original language description
The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal conditions for neuronal function. Interactions between neurons and a specialized form of ECM, perineuronal nets (PNN), are considered a key mechanism for the regulation of brain plasticity. Such an assembly of interconnected structural and regulatory molecules has a prominent role in the control of synaptic plasticity. In this review, we discuss novel ways of studying the interplay between PNN and its regulatory components, particularly tenascins, in the processes of synaptic plasticity, mechanotransduction, and neurogenesis. Since enhanced neuronal activity promotes PNN degradation, it is possible to study PNN remodeling as a dynamical change in the expression and organization of its constituents that is reflected in its ultrastructure. The discovery of these subtle modifications is enabled by the development of super-resolution microscopy and advanced methods of image analysis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
10
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
1345
UT code for WoS article
000667372300001
EID of the result in the Scopus database
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