Role of MCC/Eisosome in Fungal Lipid Homeostasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00517827" target="_blank" >RIV/68378041:_____/19:00517827 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2218-273X/9/8/305" target="_blank" >https://www.mdpi.com/2218-273X/9/8/305</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom9080305" target="_blank" >10.3390/biom9080305</a>
Alternative languages
Result language
angličtina
Original language name
Role of MCC/Eisosome in Fungal Lipid Homeostasis
Original language description
One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain. It is stabilized on its cytosolic face by the eisosome, a hemitubular protein complex composed of Bin/Amphiphysin/Rvs (BAR) domain-containing Pil1 and Lsp1. These two proteins bind directly to phosphatidylinositol 4,5-bisphosphate and promote the typical furrow-like shape of the microdomain, with highly curved edges and bottom. While some proteins display stable localization in the MCC/eisosome, others enter or leave it under particular conditions, such as misbalance in membrane lipid composition, changes in membrane tension, or availability of specific nutrients. These findings reveal that the MCC/eisosome, a plasma membrane microdomain with distinct morphology and lipid composition, acts as a multifaceted regulator of various cellular processes including metabolic pathways, cellular morphogenesis, signalling cascades, and mRNA decay. In this minireview, we focus on the MCC/eisosome's proposed role in the regulation of lipid metabolism. While the molecular mechanisms of the MCC/eisosome function are not completely understood, the idea of intracellular processes being regulated at the plasma membrane, the foremost barrier exposed to environmental challenges, is truly exciting.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/GA19-04052S" target="_blank" >GA19-04052S: Function of specific membrane microdomains in lipid homeostasis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomolecules
ISSN
2218-273X
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
305
UT code for WoS article
000484457600010
EID of the result in the Scopus database
2-s2.0-85070465240