Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459661" target="_blank" >RIV/68378041:_____/16:00459661 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1091/mbc.E16-01-0065" target="_blank" >http://dx.doi.org/10.1091/mbc.E16-01-0065</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1091/mbc.E16-01-0065" target="_blank" >10.1091/mbc.E16-01-0065</a>

Result language
angličtina
Original language name
Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans.
Original language description
The plasma membrane of the fungal pathogen Candida albicans mediates many processes needed for virulence. We examined, using among others the analysis of freeze-etched membrane replicas, plasma membrane microdomains termed membrane compartment of Can1 (MCC). Mutant which failed to form MCC displayed strong defects in plasma membrane organization and morphogenesis. We showed that integral membrane protein Sur7 and soluble, membrane-attached proteins Pil1 and Lsp1 affect overlapping but distinct functions. In support of this, many mutant phenotypes of the pil1Δ lsp1Δ cells were rescued by overexpressing SUR7. These results demonstrate that C. albicans MCC promote the ability of Sur7 to regulate plasma membrane organization.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
<a href="/en/project/GA15-10641S" target="_blank" >GA15-10641S: Specific plasma membrane microdomains in regulation of aging</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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