Lateral Compartmenation of Proteins and Lipids in the Plasma Membrane: Involvement of the Membrane Potential

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00097541" target="_blank" >RIV/61388971:_____/07:00097541 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/07:00097541

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lateral Compartmenation of Proteins and Lipids in the Plasma Membrane: Involvement of the Membrane Potential

Original language description

The membrane potential is mainly considered as the driving force for ion and nutrient translocation. We have discovered a novel role of the membrane potential in the organization of the plasma membrane. Within the yeast plasma membrane, two non-overlapping sub-compartements have been visualized (1). The first one, represented by a network-like structure, is occupied by the proton ATPase, Pma1, and the second one, forming 300 nm patches, houses a number of proton symporters (Can1, Fur4, Tat2) and the Sur7-protein. We show that sterols, the main lipid constituent of the plasma membrane, also accumulate within the patchy compartment (2). This compartmentation is highly dependent on energization. Membrane depolarization causes reversible dispersion of theH+-symporters, not however of the Sur7 protein. Mitochondrial mutants affected in the plasma membrane energization, show a significantly lower degree of membrane protein segregation

Czech name

Laterální kompartmentace proteinů a lipidů v plasmatické membráně: Role membránového potenciálu

Czech description

Membránový potenciál je zdrojem síly řídící akumulaci substrátů v buňkách. My jsme objevili novou roli, kterou membránový potenciál hraje v organizaci plasmatické membrány. Plasmatická membrána je subkomapartmentalizovaná do dvou nepřesahujících se kompártmentů. Jeden je osídlen Pma1p a druhý několika symportéry a Sur7. Steroly jsou akumulovány v subkompartmentu 2. Depolarizace membránového potenciálu způsobuje reversibilní dispersi symportérů, neovlivňuje však rozmístění Sur7 nebo Pma1p

Type

D - Article in proceedings

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Annual Conference on Yeasts /35./. Programme. Abstracts

ISBN

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ISSN

1336-4839

e-ISSN

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Number of pages

1

Pages from-to

34-34

Publisher name

SAS

Place of publication

Bratislava

Event location

Smolenice

Event date

May 16, 2007

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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