Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00517908" target="_blank" >RIV/68378041:_____/19:00517908 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10394483 RIV/00216208:11140/19:10394483
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1383574219300080?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1383574219300080?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrrev.2019.05.002" target="_blank" >10.1016/j.mrrev.2019.05.002</a>
Alternative languages
Result language
angličtina
Original language name
Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review
Original language description
The development of minimally invasive and low-cost assay enabling early diagnosis, treatment response and prognosis in cancer patients may provide a promising alternative to tumor biopsy. Circulating cell-free DNA (cfDNA) is probably the most promising tool among all components of liquid biopsy. This review includes studies exploring cfDNA as the diagnostic, prognostic or predictive biomarker for all types of cancer. In this article, we systematically reviewed the relevant literature from PubMed about cfDNA. All articles presented higher cfDNA concentration in cancer patients when compared with patients with benign disease or healthy individuals. Most of the articles showed a connection between cfDNA and prognosis. The presence of high cfDNA level in serum or plasma was associated with worse overall patient's survival. This review supports the idea that the cfDNA analysis represents a promising research area and hopefully in the future, could be applied as a new biomarker for cancer detection, prognosis determination and prediction of the response to therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research-Reviews in Mutation Research
ISSN
1383-5742
e-ISSN
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Volume of the periodical
781
Issue of the periodical within the volume
jul.-sep.
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
30
Pages from-to
100-129
UT code for WoS article
000482872300008
EID of the result in the Scopus database
2-s2.0-85065765334