The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518180" target="_blank" >RIV/68378041:_____/19:00518180 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41583-019-0196-3" target="_blank" >https://www.nature.com/articles/s41583-019-0196-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41583-019-0196-3" target="_blank" >10.1038/s41583-019-0196-3</a>
Alternative languages
Result language
angličtina
Original language name
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Original language description
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Reviews Neuroscience
ISSN
1471-0048
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
451-465
UT code for WoS article
000476622300005
EID of the result in the Scopus database
2-s2.0-85068458252