The potential of memory enhancement through modulation of perineuronal nets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518209" target="_blank" >RIV/68378041:_____/19:00518209 - isvavai.cz</a>
Result on the web
<a href="https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14672" target="_blank" >https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14672</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bph.14672" target="_blank" >10.1111/bph.14672</a>
Alternative languages
Result language
angličtina
Original language name
The potential of memory enhancement through modulation of perineuronal nets
Original language description
With an increasingly aging global population, the incidence of neurological diseases such as dementia is set to increase to unmanageable levels, yet there are currently only symptomatic therapies available for treatment. The mechanisms underlying the development of some forms of dementia, such as Alzheimer's disease (AD), are not yet completely elucidated with several competing hypotheses existing. During the closure of the critical period in the brain, significant compositional changes occur to the neural extracellular matrix (ECM). Specifically, condensed mesh-like structures called perineuronal nets (PNNs) form around subsets of neurons and have a profound effect on axonal growth and limit neuronal plasticity. These PNNs act as a morphological checkpoint and can influence memory and cognition. Manipulating these important ECM structures may provide the key to reactivating plasticity and restoring memory, both of which are severely impaired in AD and other associated neurological diseases. This review explores the current understanding of how PNNs are manipulated and examines potential new methods for PNN modulation. Linked Articles This article is part of a themed section on Therapeutics for Dementia and Alzheimer's Disease: New Directions for Precision Medicine. To view the other articles in this section visit
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Pharmacology
ISSN
0007-1188
e-ISSN
—
Volume of the periodical
176
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
3611-3621
UT code for WoS article
000483720600015
EID of the result in the Scopus database
2-s2.0-85066095354