Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00525487" target="_blank" >RIV/68378041:_____/20:00525487 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/20:00525487 RIV/00216208:11130/20:10412359 RIV/61989592:15310/20:73605171
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2211124720307579?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2211124720307579?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2020.107777" target="_blank" >10.1016/j.celrep.2020.107777</a>
Alternative languages
Result language
angličtina
Original language name
Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain
Original language description
Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we perform a comprehensive RNA-seq analysis of aging, ischemic stroke, and their interaction in 3- and 18-month-old mice. We assess differential gene expression across injury status and age, estimate cell type proportion changes, assay the results against a range of transcriptional signatures from the literature, and perform unsupervised co-expression analysis, identifying modules of genes with varying response to injury. We uncover downregulation of axonal and synaptic maintenance genetic program, and increased activation of type I interferon (IFN-I) signaling following stroke in aged mice. Together, these results paint a picture of ischemic stroke as a complex age-related disease and provide insights into interaction of aging and stroke on cellular and molecular level.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
27
Pages from-to
107777
UT code for WoS article
000541973800019
EID of the result in the Scopus database
2-s2.0-85086381872