DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539304" target="_blank" >RIV/68378041:_____/20:00539304 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/20:10412352 RIV/75010330:_____/20:00013321 RIV/00216208:11110/20:10412352 RIV/00216208:11120/20:43920273
Result on the web
<a href="https://www.mdpi.com/2072-6694/12/7/1713" target="_blank" >https://www.mdpi.com/2072-6694/12/7/1713</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers12071713" target="_blank" >10.3390/cancers12071713</a>
Alternative languages
Result language
angličtina
Original language name
DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
Original language description
There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, high-penetrance germline mutations in DNA repair genes are important players in familial cancers:BRCA1,BRCA2mutations or mismatch repair, and polymerase deficiency in colorectal, breast, and ovarian cancers. Recently, some molecular hallmarks (e.g.,TP53,KRAS,BRAF,RAD51C/DorPTENmutations) of ovarian carcinomas were identified. The manuscript overviews the role of DNA repair machinery in ovarian cancer, its risk, prognosis, and therapy outcome. We have attempted to expose molecular hallmarks of ovarian cancer with a focus on DNA repair system and scrutinized genetic, epigenetic, functional, and protein alterations in individual DNA repair pathways (homologous recombination, non-homologous end-joining, DNA mismatch repair, base- and nucleotide-excision repair, and direct repair). We suggest that lack of knowledge particularly in non-homologous end joining repair pathway and the interplay between DNA repair pathways needs to be confronted. The most important genes of the DNA repair system are emphasized and their targeting in ovarian cancer will deserve further attention. The function of those genes, as well as the functional status of the entire DNA repair pathways, should be investigated in detail in the near future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancers (Basel)
ISSN
2072-6694
e-ISSN
—
Volume of the periodical
12
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
37
Pages from-to
1713
UT code for WoS article
000556366400001
EID of the result in the Scopus database
2-s2.0-85086923920