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Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539305" target="_blank" >RIV/68378041:_____/20:00539305 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11140/20:10409737 RIV/00216208:11110/20:10409737

  • Result on the web

    <a href="https://academic.oup.com/mutage/article-abstract/35/3/261/5743334?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/mutage/article-abstract/35/3/261/5743334?redirectedFrom=fulltext</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/mutage/geaa005" target="_blank" >10.1093/mutage/geaa005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer

  • Original language description

    Colorectal cancer (CRC) continues to be one of the leading malignancies and causes of tumour-related deaths worldwide. Both impaired DNA repair mechanisms and disrupted telomere length homeostasis represent key culprits in CRC initiation, progression and prognosis. Mechanistically, altered DNA repair results in the accumulation of mutations in the genome and, ultimately, in genomic instability. DNA repair also determines the response to chemotherapeutics in CRC treatment, suggesting its utilisation in the prediction of therapy response and individual approach to patients. Telomere attrition resulting in replicative senescence, simultaneously bypassing cell cycle checkpoints, is a hallmark of malignant transformation of the cell. Telomerase is almost ubiquitous in advanced solid cancers, including CRC, and its expression is fundamental to cell immortalisation. Therefore, there is a persistent effort to develop therapeutics, which are telomerase-specific and gentle to non-malignant tissues. However, in practice, we are still at the level of clinical trials. The current state of knowledge and the route, which the research takes, gives us a positive perspective that the problem of molecular models of telomerase activation and telomere length stabilisation will finally be solved. We summarise the current literature herein, by pointing out the crosstalk between proteins involved in DNA repair and telomere length homeostasis in relation to CRC.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutagenesis

  • ISSN

    0267-8357

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    261-271

  • UT code for WoS article

    000593117600005

  • EID of the result in the Scopus database

    2-s2.0-85084551221