Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539953" target="_blank" >RIV/68378041:_____/20:00539953 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00429-020-02104-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs00429-020-02104-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00429-020-02104-8" target="_blank" >10.1007/s00429-020-02104-8</a>

Result language

angličtina

Original language name

Postnatal exposure to an acoustically enriched environment alters the morphology of neurons in the adult rat auditory system

Original language description

The structure of neurons in the central auditory system is vulnerable to various kinds of acoustic exposures during the critical postnatal developmental period. Here we explored long-term effects of exposure to an acoustically enriched environment (AEE) during the third and fourth weeks of the postnatal period in rat pups. AEE consisted of a spectrally and temporally modulated sound of moderate intensity, reinforced by a behavioral paradigm. At the age of 3-6 months, a Golgi-Cox staining was used to evaluate the morphology of neurons in the inferior colliculus (IC), the medial geniculate body (MGB), and the auditory cortex (AC). Compared to controls, rats exposed to AEE showed an increased mean dendritic length and volume and the soma surface in the external cortex and the central nucleus of the IC. The spine density increased in both the ventral and dorsal divisions of the MGB. In the AC, the total length and volume of the basal dendritic segments of pyramidal neurons and the number and density of spines on these dendrites increased significantly. No differences were found on apical dendrites. We also found an elevated number of spines and spine density in non-pyramidal neurons. These results show that exposure to AEE during the critical developmental period can induce permanent changes in the structure of neurons in the central auditory system. These changes represent morphological correlates of the functional plasticity, such as an improvement in frequency tuning and synchronization with temporal parameters of acoustical stimuli.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Structure & Function

ISSN

1863-2661

e-ISSN

—

Volume of the periodical

225

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

17

Pages from-to

1979-1995

UT code for WoS article

000543316000001

EID of the result in the Scopus database

2-s2.0-85087059597