Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00540030" target="_blank" >RIV/68378041:_____/20:00540030 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10413041
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/rme-2019-0145" target="_blank" >https://www.futuremedicine.com/doi/10.2217/rme-2019-0145</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/rme-2019-0145" target="_blank" >10.2217/rme-2019-0145</a>
Alternative languages
Result language
angličtina
Original language name
Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?
Original language description
Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Regenerative Medicine
ISSN
1746-0751
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
29
Pages from-to
1463-1491
UT code for WoS article
000539326200007
EID of the result in the Scopus database
2-s2.0-85084693491