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Changes in cryopreserved cell nuclei serve as indicators of processes during freezing and thawing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00507904" target="_blank" >RIV/68378271:_____/19:00507904 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/19:00507904

  • Result on the web

    <a href="https://doi.org/10.1021/acs.langmuir.8b02742" target="_blank" >https://doi.org/10.1021/acs.langmuir.8b02742</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acs.langmuir.8b02742" target="_blank" >10.1021/acs.langmuir.8b02742</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Changes in cryopreserved cell nuclei serve as indicators of processes during freezing and thawing

  • Original language description

    The mechanisms underlying cell protection from cryoinjury are not yet fully understood. Recent biological studies have addressed cryopreserved cell survival but have not correlated the cryoprotection effectiveness with the impact of cryoprotectants on the most important cell structure, the nucleus, and the freeze/thaw process. We identified changes of cell nuclei states caused by different types of cryoprotectants and associate them with alterations of the freeze/thaw process in cells. Namely, we investigated both higher-order chromatin structure and nuclear envelope integrity as possible markers of freezing and thawing processes. Moreover, we analysed in detail the relationship between nuclear envelope integrity, chromatin condensation, freeze/thaw processes in cells and cryopreservation efficiency for DMSO, glycerol, trehalose and antifreeze protein.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Langmuir

  • ISSN

    0743-7463

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    23

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    7496-7508

  • UT code for WoS article

    000471728600021

  • EID of the result in the Scopus database

    2-s2.0-85056124752