Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00540031" target="_blank" >RIV/68378041:_____/20:00540031 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/20:00537561 RIV/00023001:_____/20:00080456
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0168365920304776?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0168365920304776?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2020.08.036" target="_blank" >10.1016/j.jconrel.2020.08.036</a>
Alternative languages
Result language
angličtina
Original language name
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications
Original language description
Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification. We describe mechanisms of IONPs-induced toxicity. Ultimately, we demonstrate that knowledge of cellular mechanisms of IONPs action helped to overcome certain translation problems in nanomedicine - we explore potential causes and challenges associated with poor clinical performance of IONPs and propose outlook of how to overcome problems in the field. Our critical analysis implies that a clear understanding of molecular mechanisms of IONPs-cell interactions will provide a basement to increase the likelihood for clinical success of IONPs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/LTC19040" target="_blank" >LTC19040: Advanced physical methods in hepatotoxicity studies</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Controlled Release
ISSN
0168-3659
e-ISSN
—
Volume of the periodical
328
Issue of the periodical within the volume
dec.
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
19
Pages from-to
59-77
UT code for WoS article
000600791600005
EID of the result in the Scopus database
2-s2.0-85089899628