Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00574215" target="_blank" >RIV/68378271:_____/23:00574215 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/23:00084083
Result on the web
<a href="https://hdl.handle.net/11104/0344559" target="_blank" >https://hdl.handle.net/11104/0344559</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D3NA00071K" target="_blank" >10.1039/D3NA00071K</a>
Alternative languages
Result language
angličtina
Original language name
Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells
Original language description
Iron oxide nanoparticles (IONPs) are being actively researched in various biomedical applications, particularly as magnetic resonance imaging contrast agents for diagnosing various liver pathologies. Emerging evidence suggests that IONPs may exacerbate hepatic steatosis and liver injury in susceptible livers. However, our understanding of how IONPs may affect steatotic cells at the sub-cellular level is still fragmented. In this study, we demonstrate that IONPs, at a dose that does not cause general toxicity in hepatic cells, induce significant toxicity in steatotic cells. Mechanistically, co-treatment with palmitic acid and IONPs resulted in endoplasmic reticulum (ER) stress, accompanied by the release of cathepsin B from lysosomes to the cytosol. The release of cathepsin B, along with ER stress, led to the activation of apoptotic cell death. This study provides important basic knowledge for the future optimization of IONPs as MRI contrast agents for various biomedical applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale Advances
ISSN
2516-0230
e-ISSN
2516-0230
Volume of the periodical
5
Issue of the periodical within the volume
16
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
4250-4268
UT code for WoS article
001037449000001
EID of the result in the Scopus database
2-s2.0-85167418563