Ultrafine particles and their possible role in etiology and development of neurodegenerative diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00560378" target="_blank" >RIV/68378041:_____/20:00560378 - isvavai.cz</a>

Result on the web

<a href="https://dx.doi.org/10.37904/nanocon.2019.8558" target="_blank" >https://dx.doi.org/10.37904/nanocon.2019.8558</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2019.8558" target="_blank" >10.37904/nanocon.2019.8558</a>

Result language

angličtina

Original language name

Ultrafine particles and their possible role in etiology and development of neurodegenerative diseases

Original language description

Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, chronic obstructive pulmonary disease) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer's disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. Our new H2020 project TUBE aims on revealing the mechanisms of action of ultrafine particles involved in neurological diseases. The TUBE consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. We will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming to a comprehensive understanding of the adverse brain effects of nanoparticles from traffic.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30305 - Occupational health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./

ISBN

978-80-87294-95-6

ISSN

—

e-ISSN

—

Number of pages

5

Pages from-to

705-709

Publisher name

Tanger Ltd.

Place of publication

Ostrava

Event location

Brno

Event date

Oct 16, 2019

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000664115400121