Application potential of screening in vitro toxicological assays in qualitative risk assessment of nanomaterials

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00560386" target="_blank" >RIV/68378041:_____/20:00560386 - isvavai.cz</a>

Result on the web

<a href="https://www.confer.cz/nanocon/2019/93-application-potential-of-screening-in-vitro-toxicological-assays-in-qualitative-risk-assessment-of-nanomaterials" target="_blank" >https://www.confer.cz/nanocon/2019/93-application-potential-of-screening-in-vitro-toxicological-assays-in-qualitative-risk-assessment-of-nanomaterials</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2019.8687" target="_blank" >10.37904/nanocon.2019.8687</a>

Result language

angličtina

Original language name

Application potential of screening in vitro toxicological assays in qualitative risk assessment of nanomaterials

Original language description

Undeniable benefits of engineered nanomaterials might be discredited by their potential enhanced or unexpected toxicity arising from nano-specific properties and behavior. An analysis of the applicability of the traditional chemical risk assessment approach in nanomaterials revealed high levels of uncertainty in both hazard characterization and exposure assessment due to the lack of relevant validated methods and reliable data. This indicates the limited capability of the conventional risk assessment approach to ensure the safe use of nanomaterials. Based on the identified uncertainties, the control banding approach was proposed as a suitable tool for preliminary qualitative risk assessment of nanomaterials in occupational settings. Control banding categorizes hazard and exposure into levels referred to as bands. The combination of the hazard and exposure bands results in a risk band determining the necessary degree of control and regulatory measures. To decrease the number of cases where, based on the precautionary principle, unavailable experimental or field data would lead to the assignment to the highest hazard category requiring costly exposure control, screening evaluation of nanomaterial toxicity was proposed as an additional decision criterion. For this purpose, a battery of in vitro toxicological assays enabling screening evaluation of potential toxic effects of NMs was proposed. The assays evaluate endpoints covering basic toxic effects of substances (cytotoxicity, genotoxicity), as well as known nonspecific mechanisms of toxicity typical for nanomaterials (oxidative stress, inflammation). The proposed risk management strategy is intended to assist small and medium-sized enterprises to implement adequate measures to ensure employee safety.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./

ISBN

978-80-87294-95-6

ISSN

—

e-ISSN

—

Number of pages

6

Pages from-to

491-496

Publisher name

Tanger Ltd.

Place of publication

Ostrava

Event location

Brno

Event date

Oct 16, 2019

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000664115400084