Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00577511" target="_blank" >RIV/68378041:_____/20:00577511 - isvavai.cz</a>
Result on the web
<a href="https://www.scientific.net/KEM.834.162" target="_blank" >https://www.scientific.net/KEM.834.162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >10.4028/www.scientific.net/KEM.834.162</a>
Alternative languages
Result language
angličtina
Original language name
Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering
Original language description
Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ε-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering. © 2020 Trans Tech Publications Ltd, Switzerland.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Key Engineering Materials
ISBN
978-303571519-4
Number of pages of the result
7
Pages from-to
162-168
Number of pages of the book
196
Publisher name
Scientific
Place of publication
Bäch
UT code for WoS chapter
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