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Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F20%3A00346727" target="_blank" >RIV/68407700:21720/20:00346727 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.162</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >10.4028/www.scientific.net/KEM.834.162</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering

  • Original language description

    Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ε-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30213 - Transplantation

Result continuities

  • Project

    <a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Key Engineering Materials Vol. 834

  • ISBN

    9783035715194

  • ISSN

    1013-9826

  • e-ISSN

  • Number of pages

    7

  • Pages from-to

    162-168

  • Publisher name

    Trans Tech Publications Ltd.

  • Place of publication

    Pfaffikon

  • Event location

    Salt lake city

  • Event date

    Aug 2, 2019

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article