Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F20%3A00346727" target="_blank" >RIV/68407700:21720/20:00346727 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.162" target="_blank" >10.4028/www.scientific.net/KEM.834.162</a>
Alternative languages
Result language
angličtina
Original language name
Coaxial nanofibrous scaffold prepared using centrifugal spinning as a drug delivery system for skeletal tissue engineering
Original language description
Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ε-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
<a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Key Engineering Materials Vol. 834
ISBN
9783035715194
ISSN
1013-9826
e-ISSN
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Number of pages
7
Pages from-to
162-168
Publisher name
Trans Tech Publications Ltd.
Place of publication
Pfaffikon
Event location
Salt lake city
Event date
Aug 2, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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