An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00538432" target="_blank" >RIV/68378041:_____/21:00538432 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41370-020-0253-z" target="_blank" >https://www.nature.com/articles/s41370-020-0253-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41370-020-0253-z" target="_blank" >10.1038/s41370-020-0253-z</a>

Result language

angličtina

Original language name

An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process

Original language description

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the endocrine system and cause adverse effects. We aimed to classify the effects of 24 known EDCs, prevalent in certain occupations, according to four modes of action (estrogenic, antiestrogenic, androgenic, and/or antiandrogenic). A literature search, stratified into four types of literature was conducted (namely: national and international agency reports, review articles, primary studies, ToxCast(TM)). The state of the evidence of each EDC on sex hormone function was summarized and reviewed by an expert panel. For each mode of action, the experts evaluated the likelihood of endocrine disruption in five categories: No, Unlikely, Possibly, Probably, and Yes. Seven agents were categorized as Yes, or having strong evidence for their effects on sex hormone function (antiandrogenic: lead, arsenic, butylbenzyl phthalate, dibutyl phthalate, dicyclohexyl phthalate, estrogenic: nonylphenol, bisphenol A). Nine agents were categorized as Probable, or having probable evidence (antiandrogenic: bis(2-ethylhexyl)phthalate, nonylphenol, toluene, bisphenol A, diisononyl phthalate, androgenic: cadmium, estrogenic: copper, cadmium and, anti-estrogenic: lead). Two agents (arsenic, polychlorinated biphenyls) had opposing conclusions supporting both probably estrogenic and antiestrogenic effects. This synthesis will allow researchers to evaluate the health effects of selected EDCs with an added level of precision related to the mode of action.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30305 - Occupational health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Exposure Science and Environmental Epidemiology

ISSN

1559-0631

e-ISSN

1559-064X

Volume of the periodical

31

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

753-768

UT code for WoS article

000551804500001

EID of the result in the Scopus database

2-s2.0-85088456694