The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00551800" target="_blank" >RIV/68378041:_____/21:00551800 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2075-4426/11/1/60" target="_blank" >https://www.mdpi.com/2075-4426/11/1/60</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jpm11010060" target="_blank" >10.3390/jpm11010060</a>
Alternative languages
Result language
angličtina
Original language name
The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development
Original language description
Small non-coding RNA molecules (miRNAs) play an important role in the epigenetic regulation of gene expression. As these molecules have been repeatedly implicated in human cancers, they have been suggested as biomarkers of the disease. Additionally, miRNA levels have been shown to be affected by environmental pollutants, including airborne contaminants. In this review, we searched the current literature for miRNAs involved in lung cancer, as well as miRNAs deregulated as a result of exposure to air pollutants. We then performed a synthesis of the data and identified those molecules commonly deregulated under both conditions. We detected a total of 25 miRNAs meeting the criteria, among them, miR-222, miR-21, miR-126-3p, miR-155 and miR-425 being the most prominent. We propose these miRNAs as biomarkers of choice for the identification of human populations exposed to air pollution with a significant risk of developing lung cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Personalized Medicine
ISSN
2075-4426
e-ISSN
2075-4426
Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
60
UT code for WoS article
000610343200001
EID of the result in the Scopus database
2-s2.0-85099862182