The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552886" target="_blank" >RIV/68378041:_____/21:00552886 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/14/7529" target="_blank" >https://www.mdpi.com/1422-0067/22/14/7529</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22147529" target="_blank" >10.3390/ijms22147529</a>
Alternative languages
Result language
angličtina
Original language name
The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage
Original language description
The mandibular and hyoid arches collectively make up the facial skeleton, also known as the viscerocranium. Although all three germ layers come together to assemble the pharyngeal arches, the majority of tissue within viscerocranial skeletal components differentiates from the neural crest. Since nearly one third of all birth defects in humans affect the craniofacial region, it is important to understand how signalling pathways and transcription factors govern the embryogenesis and skeletogenesis of the viscerocranium. This review focuses on mouse and zebrafish models of craniofacial development. We highlight gene regulatory networks directing the patterning and osteochondrogenesis of the mandibular and hyoid arches that are actually conserved among all gnathostomes. The first part of this review describes the anatomy and development of mandibular and hyoid arches in both species. The second part analyses cell signalling and transcription factors that ensure the specificity of individual structures along the anatomical axes. The third part discusses the genes and molecules that control the formation of bone and cartilage within mandibular and hyoid arches and how dysregulation of molecular signalling influences the development of skeletal components of the viscerocranium. In conclusion, we notice that mandibular malformations in humans and mice often co-occur with hyoid malformations and pinpoint the similar molecular machinery controlling the development of mandibular and hyoid arches.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
14
Country of publishing house
CH - SWITZERLAND
Number of pages
34
Pages from-to
7529
UT code for WoS article
000677342000001
EID of the result in the Scopus database
2-s2.0-85110746379