Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00538310" target="_blank" >RIV/68378041:_____/20:00538310 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/20:00540134 RIV/00216208:11310/20:10412215
Result on the web
<a href="https://bio.biologists.org/content/9/6/bio052043" target="_blank" >https://bio.biologists.org/content/9/6/bio052043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/bio.052043" target="_blank" >10.1242/bio.052043</a>

Result language
angličtina
Original language name
Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway
Original language description
Cranial neural crest cells (cNCCs) originate in the anterior neural tube and populate pharyngeal arches in which they contribute to formation of bone and cartilage. This cell population also provides molecular signals for the development of tissues of non-neural crest origin, such as the tongue muscles, teeth enamel or gland epithelium. Here we show that the transcription factor Meis2 is expressed in the oral region of the first pharyngeal arch (PA1) and later in the tongue primordium. Conditional inactivation of Meis2 in cNCCs resulted in loss of Sonic hedgehog signalling in the oropharyngeal epithelium and impaired patterning of PA1 along the lateral-medial and oral-aboral axis. Failure of molecular specification of PA1, illustrated by altered expression of Hand1/2, Dlx5, Barx1, Gsc and other markers, led to hypoplastic tongue and ectopic ossification of the mandible. Meis2-mutant mice thus display craniofacial defects that are reminiscent of several human syndromes and patients with mutations in the Meis2 gene.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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