Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00601685" target="_blank" >RIV/68378041:_____/25:00601685 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00140932 RIV/00216208:11310/25:10515634

Result on the web

<a href="https://elifesciences.org/articles/100854" target="_blank" >https://elifesciences.org/articles/100854</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.100854.1" target="_blank" >10.7554/eLife.100854.1</a>

Result language

angličtina

Original language name

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

Original language description

Hair follicle development is initiated by reciprocal molecular interactions between the placode-forming epithelium and the underlying mesenchyme. Cell fate transformation in dermal fibroblasts generates cell niche for placode induction by activation of signaling pathways WNT, EDA and FGF in epithelium. These successive paracrine epithelial signals initiate dermal condensation in the underlying mesenchyme. Although epithelial signaling from the placode to mesenchyme is better described, little is known about primary mesenchymal signals resulting in placode induction. Here we show that Meis2 expression in cells derived from the neural crest is critical for whisker formation, and also for branching of trigeminal nerves. While whisker formation is independent of the trigeminal sensory innervation, MEIS2 in mesenchymal dermal cells orchestrates initial steps of epithelial placode formation and subsequent dermal condensation. MEIS2 regulates the expression of transcription factor Foxd1 which is typical of pre-dermal condensation. However, deletion of Foxd1 does not affect whisker development. Overall, our data report an early role of mesenchymal MEIS2 during whisker formation and provide evidence that whiskers can normally develop in the absence of sensory innervation or FOXD1 expression.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

2050-084X

Volume of the periodical

13

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

21

Pages from-to

RP100854

UT code for WoS article

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EID of the result in the Scopus database

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