Meis2 is essential for cranial and cardiac neural crest development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455864" target="_blank" >RIV/68378050:_____/15:00455864 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12861-015-0093-6" target="_blank" >http://dx.doi.org/10.1186/s12861-015-0093-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12861-015-0093-6" target="_blank" >10.1186/s12861-015-0093-6</a>

Result language

angličtina

Original language name

Meis2 is essential for cranial and cardiac neural crest development

Original language description

Background: TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 documented specific functions in embryogenesis, however, functional studies of Meis2 in mouse are still missing. We have generated a conditional allele of Meis2 in mice and shown that systemic inactivation of the Meis2 gene results in lethality by the embryonic day 14 that is accompaniedwith hemorrhaging.nnResults: We show that neural crest cells express Meis2 and Meis2-defficient embryos display defects in tissues that are derived from the neural crest, such as an abnormal heart outflow tract with the persistent truncus arteriosus and abnormal cranial nerves. The importance of Meis2 for neural crest cells is further confirmed by means of conditional inactivation of Meis2 using crest-specific AP2a-IRES-Cre mouse. Conditional mutants display perturbed development of t

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Developmental Biology

ISSN

1471-213X

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

Nov 6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

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UT code for WoS article

000364545600001

EID of the result in the Scopus database

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