Investigating the role of mechanosensing via PIEZO channels in neural crest derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144444" target="_blank" >RIV/00216224:14110/25:00144444 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Investigating the role of mechanosensing via PIEZO channels in neural crest derivatives
Original language description
Neural crest is a transient population of cells formed during embryonic development that gives rise to multiple cell types, including mesenchymal cells, autonomic and sensory neurons, glia, and melanocytes. During morphogenesis, cells must respond to external cues, such as the mechanical properties of their microenvironment, to guide their migration and regulate their lineage commitment. Disruption in any of these processes can subsequently lead to developmental abnormalities and diverse disorders. However, the involvement of mechanical forces and mechanosensing in the development of neural crest-derived tissues still remains poorly understood. In this project, we explore the role of mechanosensing mediated by the mechanically gated ion channels PIEZO1 and PIEZO2 in neural crest derivatives in vivo. Using genetically engineered mouse models with tamoxifen-inducible double knockout of Piezo1 and Piezo2 in Sox10-expressing cells, we examine the effect of Piezo1/2 deletion during: (i) embryonic development and (ii) adult tissue homeostasis. We suggest that proper mechanosensing is essential for both the formation of neural crest-derived structures during embryogenesis and their maintenance during adulthood. Our work will provide new insights into how Piezo1/2 signalling shapes the structures of neural crest origin and contribute to a broader understanding of the role of mechanical forces in developmental biology.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/GA25-18087S" target="_blank" >GA25-18087S: Cellular Basis of Dental Healing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů