Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00554922" target="_blank" >RIV/68378041:_____/22:00554922 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/22:00554922 RIV/00216208:11310/22:10456249
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2021.760881/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2021.760881/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2021.760881" target="_blank" >10.3389/fimmu.2021.760881</a>
Alternative languages
Result language
angličtina
Original language name
Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse
Original language description
Differences in frequencies of blood cell subpopulations were reported to influence the course of infections, atopic and autoimmune diseases, and cancer. We have discovered a unique mouse strain B10.O20 containing extremely high frequency of myeloid-derived cells (MDC) in spleen. B10.O20 carries 3.6% of genes of the strain O20 on the C57BL/10 genetic background. It contains much higher frequency of CD11b(+)Gr1(+) cells in spleen than both its parents. B10.O20 carries O20-derived segments on chromosomes 1, 15, 17, and 18. Their linkage with frequencies of blood cell subpopulations in spleen was tested in F-2 hybrids between B10.O20 and C57BL/10. We found 3 novel loci controlling MDC frequencies: Mydc1, 2, and 3 on chromosomes 1, 15, and 17, respectively, and a locus controlling relative spleen weight (Rsw1) that co-localizes with Mydc3 and also influences proportion of white and red pulp in spleen. Mydc1 controls numbers of CD11b(+)Gr1(+) cells. Interaction of Mydc2 and Mydc3 regulates frequency of CD11b(+)Gr1(+) cells and neutrophils (Gr1(+)Siglec-F- cells from CD11b(+) cells). Interestingly, Mydc3/Rsw1 is orthologous with human segment 6q21 that was shown previously to determine counts of white blood cells. Bioinformatics analysis of genomic sequence of the chromosomal segments bearing these loci revealed polymorphisms between O20 and C57BL/10 that change RNA stability and genes' functions, and we examined expression of relevant genes. This identified potential candidate genes Smap1, Vps52, Tnxb, and Rab44. Definition of genetic control of MDC can help to personalize therapy of diseases influenced by these cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
1664-3224
Volume of the periodical
12
Issue of the periodical within the volume
January
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
760881
UT code for WoS article
000752949400001
EID of the result in the Scopus database
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