De novo emergence, existence, and demise of a protein-coding gene in murids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00567757" target="_blank" >RIV/68378041:_____/22:00567757 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/22:00567476
Result on the web
<a href="https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01470-5" target="_blank" >https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01470-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12915-022-01470-5" target="_blank" >10.1186/s12915-022-01470-5</a>
Alternative languages
Result language
angličtina
Original language name
De novo emergence, existence, and demise of a protein-coding gene in murids
Original language description
Background: Genes, principal units of genetic information, vary in complexity and evolutionary history. Less-complex genes (e.g., long non-coding RNA (lncRNA) expressing genes) readily emerge de novo from non-genic sequences and have high evolutionary turnover. Genesis of a gene may be facilitated by adoption of functional genic sequences from retrotransposon insertions. However, protein-coding sequences in extant genomes rarely lack any connection to an ancestral protein-coding sequence.nnResults: We describe remarkable evolution of the murine gene D6Ertd527e and its orthologs in the rodent Muroidea superfamily. The D6Ertd527e emerged in a common ancestor of mice and hamsters most likely as a lncRNA-expressing gene. A major contributing factor was a long terminal repeat (LTR) retrotransposon insertion carrying an oocyte-specific promoter and a 5 ' terminal exon of the gene. The gene survived as an oocyte-specific lncRNA in several extant rodents while in some others the gene or its expression were lost. In the ancestral lineage of Mus musculus, the gene acquired protein-coding capacity where the bulk of the coding sequence formed through CAG (AGC) trinucleotide repeat expansion and duplications. These events generated a cytoplasmic serine-rich maternal protein. Knock-out of D6Ertd527e in mice has a small but detectable effect on fertility and the maternal transcriptome.nnConclusions: While this evolving gene is not showing a clear function in laboratory mice, its documented evolutionary history in Muroidea during the last similar to 40 million years provides a textbook example of how a several common mutation events can support de novo gene formation, evolution of protein-coding capacity, as well as gene's demise.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC BIOLOGY
ISSN
1741-7007
e-ISSN
1741-7007
Volume of the periodical
20
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
272
UT code for WoS article
000895928900001
EID of the result in the Scopus database
2-s2.0-85143556086