Structure and function of naturally evolved de novo proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00540521" target="_blank" >RIV/61388963:_____/21:00540521 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10438955
Result on the web
<a href="https://doi.org/10.1016/j.sbi.2020.11.010" target="_blank" >https://doi.org/10.1016/j.sbi.2020.11.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sbi.2020.11.010" target="_blank" >10.1016/j.sbi.2020.11.010</a>
Alternative languages
Result language
angličtina
Original language name
Structure and function of naturally evolved de novo proteins
Original language description
Comparative evolutionary genomics has revealed that novel protein coding genes can emerge randomly from non-coding DNA. While most of the myriad of transcripts which continuously emerge vanish rapidly, some attain regulatory regions, become translated and survive. More surprisingly, sequence properties of de novo proteins are almost indistinguishable from randomly obtained sequences, yet de novo proteins may gain functions and integrate into eukaryotic cellular networks quite easily. We here discuss current knowledge on de novo proteins, their structures, functions and evolution. Since the existence of de novo proteins seems at odds with decade-long attempts to construct proteins with novel structures and functions from scratch, we suggest that a better understanding of de novo protein evolution may fuel new strategies for protein design.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GJ17-10438Y" target="_blank" >GJ17-10438Y: Terrestrial protein sequence and structure space evolution</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Structural Biology
ISSN
0959-440X
e-ISSN
1879-033X
Volume of the periodical
68
Issue of the periodical within the volume
Jun
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
175-183
UT code for WoS article
000663831200021
EID of the result in the Scopus database
2-s2.0-85100636911